PCSK9 and Hypercholesterolemia: In contrast, elevated serum levels of LDL-C, HDL-C, APOA, APOB, Pure hypercholesterolaemia, as well as the use of lipid-lowering drugs such as HMGCR inhibitors and PCSK9 inhibitors, did not exhibit statistically significant associations with either an increased or decreased risk of urinary stones.