In contrast, elevated serum levels of LDL-C, HDL-C, APOA, APOB, Pure hypercholesterolaemia, as well as the use of lipid-lowering drugs such as HMGCR inhibitors and PCSK9 inhibitors, did not exhibit statistically significant associations with either an increased or decreased risk of urinary stones. Here, HMGCR is linked to Hypercholesterolemia.