Tang et al. (2022) demonstrated that ANGPTL8 promotes adipogenic differentiation of MSCs in liver, kidney, and heart tissues by inhibiting the Wnt/β-catenin signalling pathway. This upregulates the expression of peroxisome proliferator-activated receptor γ (PPARγ) and c/EBPα and leads to bone marrow fat deposition (Sun et al., 2017). Ectopic bone marrow fat deposition is closely related to chronic metabolic diseases, such as T2DM, NAFLD, and obesity (Tang et al., 2022). Here, ANGPTL8 is linked to type 2 diabetes mellitus.