Conversely, ANGPTL8 levels are significantly increased in HCC (Wang et al., 2018), KIRC/ccRCC (Matsukawa et al., 2023; Xu et al., 2021), colon adenocarcinoma (COAD), rectum adenocarcinoma (READ), and stomach adenocarcinoma (STAD) (Xu et al., 2021). This evidence concerns the gene ANGPTL8 and hepatocellular carcinoma.