Previous studies have found that circulating ANGPTL8 levels are elevated in inflammation-related diseases, such as systemic inflammatory response syndrome (SIRS) (Zhang et al., 2017), T2DM (Chen et al., 2015), atherosclerosis (Jiao et al., 2018), and NAFLD (Vatner et al., 2018), and are associated with disease severity. The gene discussed is ANGPTL8; the disease is metabolic dysfunction-associated steatotic liver disease.