As shown in Table 1, analysis of various databases has shown significantly decreased expression of the ANGPTL8 gene in lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), breast invasive carcinoma (BRCA), glioblastoma (GBM), cholangiocarcinoma (CHOL), uterine corpus endometrial carcinoma (UCEC), bladder urothelial carcinoma (BLCA), and kidney chromophobe (KICH) compared to their respective normal samples (Xu et al., 2021; Iqbal et al., 2023). This evidence concerns the gene ANGPTL8 and invasive breast carcinoma.