Second, the interaction of the C-terminus of ANGPTL8 with sterol regulatory element binding protein 1 (SREBP1) inhibits protein kinase activated by adenosine 5′-monophosphate (AMP)-activated protein kinases (AMPK) (Navaeian et al., 2021; Lee et al., 2015); therefore, they increase lipogenesis and tumour growth and enhance tumour progression (Navaeian et al., 2021). The gene discussed is SREBF1; the disease is neoplasm.