There is a growing consensus that cell and network excitability increases in several brain areas in individuals with FXS and Fmr1-KO rodents (Gibson et al., 2008; Qiu et al., 2009; Deng and Klyachko, 2016) including hippocampus (Chuang et al., 2005; Deng et al., 2019; Booker et al., 2020; Asiminas et al., 2022). This evidence concerns the gene FMR1 and fragile X syndrome.