Kaur et al. (2009) discovered that Sdc2 expression in the corpus callosum of neonatal rats decreases dramatically with development, but hypoxia increases its expression. Our findings do not support these observations as we found significantly upregulated expression of all syndecans with the exception of Sdc2. In both aging and stroke, the expression of Sdc2 exhibited minimal variations in the mRNA levels. This evidence concerns the gene SDC2 and Stroke.