The interplay of infected tissue resident cells signaling innate immunity and subsequent adaptive recruitment of white blood cells to transform and infiltrate infected tissues was informed by correlations of the temporal meta-signatures to COVID-19 single cell RNAseq experiments, wherein expression of the chemotactic cytokine Cxcl10 was most highly associated to monocyte–macrophage lineages. Here, CXCL10 is linked to COVID-19.