SHROOM3 and chronic kidney disease: Genome-wide association studies identified that common genetic variants near the SHROOM3 gene are associated with eGFR and prevalent CKD with modest effect sizes.10,11 Plotting these GWAS show that the associated genetic variants localize around TSS1 and the 5’ end of SHROOM3 (Figure 1).18 Given their proximity to the transcription start site, it is predicted that the associated genetic variants could decrease or increase SHROOM3 expression.