SHROOM3 and Crouzon syndrome-acanthosis nigricans syndrome: In a study of 540 3-month post-transplant kidney biopsies, for each rs17319721 risk allele in the donor kidney, there were greater SHROOM3 mRNA expression (P < .05) and increased risk of chronic allograft nephropathy in the transplant recipients (odds ratio = 1.98, confidence interval = 1.10-3.59).