SHROOM3 and glomerulosclerosis: As these hallmarks were not observed in control or young mice, this raises questions about the implication of reduced Shroom3 in the regulation of podocyte loss, glomerular volume, and glomerulosclerosis.64,65 The podocyte specific knockdown of Shroom3 resulted in foot process effacement, albuminuria, and reduced glomerular volume without a loss of podocytes.