SHROOM3 and kidney disorder: Rare SHROOM3 coding variants also appear to support a link between SHROOM3 function and kidney disease.18 The highly conserved SHROOM3 missense variant, rs181194611 (Forward Strand; Risk allele frequency in general population: 0.02%; Risk allele: T, Other allele C) is located at the binding site for the protein named 14-3-3, which regulates the Hippo signaling pathway.