At the molecular level, some alterations in the apical-basolateral orientation of tubular epithelium were observed at 3 months, but there were no alterations in kidney function or blood pressure.56 Unfortunately, homozygous Shroom3 null mice die perinatally due to failure in neural tube closure, precluding postnatal analysis.6,63 These studies highlight an important role for Shroom3 in kidney development that could manifest in kidney disease under specific conditions. The gene discussed is SHROOM3; the disease is kidney disorder.