In this study, we used a monosodium iodoacetate (MIA)‐induced OA mouse model and interleukin‐1β (IL‐1β)‐induced SW1353 chondrosarcoma cells or lipopolysaccharide (LPS)‐stimulated macrophages in vitro models to study the effects of PBSL on OA. The gene discussed is IL1B; the disease is chondrosarcoma.