We assessed TAS1R3, TRPM5, and GLP‐1 expression in colon IHC, and we could show that the expression of TAS1R3 and TRPM5 was increased in the colon of mice with T2DM (Figure 9a,b,d,e; p < .01), and the expression of GLP‐1 was decreased in the colon of mice with T2DM compared with that in the normal control mice (Figure 9c,f; p < .01). Here, TAS1R3 is linked to type 2 diabetes mellitus.