A previous study (Zhai et al., 2018) showed that NG‐R1 administration ameliorated cognitive dysfunctions, insulin resistance, dyslipidemia, inflammation, and oxidative stress by activating Akt/Nrf2/HO‐1 pathway and inhibiting NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome in db/db mice. The gene discussed is RTN4R; the disease is metabolic syndrome.