Additionally, NG‐R1 could ameliorate insulin resistance, hyperinsulinemia, dyslipidemia, and inflammation in db/db mice and markedly decreased hyperglycemia‐induced oxidative stress in hippocampal neurons by activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome, demonstrating an excellent neuroprotective effect (Zhai et al., 2018). Here, RTN4R is linked to Hyperglycemia.