The transcription factor activation of NF‐κB signaling cascade has a key function in the immune and inflammatory responses of the body through the expression of several mediators such as inducible nitric oxide synthase, TNF‐α, cyclooxygenase‐2 (COX‐2), and IL‐6 in subjects affected with NAFLD (Chen, Xing, et al., 2020). This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.