In B-ALL, studies have found that IL-15 can up-regulate CXCR3 in B-cell precursors, stimulating the migration of leukemic cells towards the CXCL10 gradient, which is detectable in cerebrospinal fluid samples from patients with B-ALL (64). The gene discussed is CXCL10; the disease is precursor B-cell acute lymphoblastic leukemia.