Signal transducer and activator of transcription 4 (STAT4), a crucial component of the STATs family, potentiates cell differentiation from native CD4+ T cell to T helper cell (Th1) via interleukin (IL)‐12/MKK6/p38α mediation and participates in the immune response through the production of interferon gamma (IFN‐γ) in tumor microenvironment (TME).6, 7, 8. This evidence concerns the gene STAT4 and neoplasm.