CD44 and colorectal cancer: Sometimes, e.g., in the case of colorectal cancer, CD44 isoform 3 has been shown associated with both poor prognosis/higher recurrence rate (Yamaguchi et al., 2016) and good prognosis/lower recurrence rate (Mashita et al., 2014; Everest-Dass et al., 2023), pointing to the possible greater significance of the ratio of CD44 isoforms.