ESRP1 and head and neck squamous cell carcinoma: Further, it has been shown that ESRPs suppress cell motility in HNSCC through distinct mechanisms: ESRP1 regulates the dynamics of the actin cytoskeleton through repressing expression of the Rac1b isoform, whereas ESRP2 is involved in the regulation of cell-cell adhesion by suppressing EMТ-associated transcription factors (Ishii et al., 2014).