Zilli et al. (2021) revealed that upregulation of ERO1A significantly promotes primary breast tumour growth and lung metastatic colonization by enhancing HIF1α-VEGFA mediated angiogenesis. Zhang et al. corroborated that overexpression of ERO1A can contribute to tumour progression by accelerating hydrogen peroxide-associated epithelial-mesenchymal transition, and it may be used as a predictor for dismal prognosis in cervical cancer (Zhang et al., 2019). In PC, ERO1A has been demonstrated to boost tumour growth via augmenting aerobic glycolysis of tumour cells (Zhang et al., 2020). The gene discussed is HIF1A; the disease is breast neoplasm.