The primary findings suggest that the Child-Pugh score, Fibrosis Index, specific endoscopic findings, ultrasound parameters, portal vein diameter, presence and size of collaterals, CT scan findings, ascites, platelet counts, coagulation parameters, albumin levels, Von Willebrand factor, bilirubin levels, diabetes mellitus, and the use of beta-blocking agents in primary prophylaxis are potential predictive factors for EVB. The gene discussed is VWF; the disease is diabetes mellitus.