A total of 12 independent risk factors, including gender, drinking and smoking history, decompensation, ascites, location and size of varices, ALT, GGT, HCT and NLR levels as well as RBC count were evaluated and used to establish the ANN model, which estimated the 1-year EGVB risk. The ANN model had an AUC of 0.959. The gene discussed is GPT; the disease is varicose disease.