IL2 and breast carcinoma: To explore the synergy between NK cell-based immunotherapy and modified antibodies such as immunocytokine (e.g., IL-2 coupled antibody), Ayuso et al.143 developed an MPS that with cultured breast cancer spheroids in a 3D matrix flanked by lateral biomimetic blood vessels to explore the synergy between NK cell-based immunotherapy and modified antibodies such as immunocytokines (e.g., IL-2 coupled antibody).