A study designed to examine the diabetic and diabetic nephropathy effects on diabetic rats revealed that administering biochanin-A markedly reduced the expression of transforming growth factor-β1 (TGF-β1), protease-activated receptors 2 (PAR-2) genes, and fasting blood glucose (FBG) (Amriet al., 2021). This evidence concerns the gene F2RL1 and diabetic kidney disease.