Curcumin exerts protective effects against liver diseases associated with oxidative damage suppressing the lipid peroxidation products, pro-inflammatory cytokines, and hepatic stellate cells and PI3K/Akt activation, as well as enhancing the expression of SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione), GPx (glutathione peroxidase), GR (glutathione reductase) and Nrf2 (Farzaei et al., 2018 ▶). The gene discussed is GSR; the disease is liver disorder.