CASP8 and Parkinson disease: In addition, administration of silibinin (70, 140, and 280 mg/kg) in MPTP-injected experimental model of PD significantly rescuedapoptosis via decreasing the protein levels of Bax, cleaved-caspase-3, cleaved-caspase-8, and cleaved-caspase-9 and increasing B-cell lymphoma 2 (Bcl-2).