LEP and metabolic dysfunction-associated steatohepatitis: Moreover, in a high-fat diet-induced NAFLD/nonalcoholic steatohepatitis mouse model study, oral administration of curcumin reduced intrahepatic CD4+ cell accumulation and the underlying linoleic acid- and leptin-induced pro-inflammatory and pro-oxidant effects on mouse liver macrophages (Inzaugarat et al., 2017 ▶).