IL21 and autoimmune disease: More importantly, IL-2 and IL-21 with their receptor subunits are also upregulated in patients diagnosed with IBD [46, 106–109], demonstrating that blockade of multiple γc cytokines through specific inhibition of JAK3 signaling cascade via anti-γc antibody might serve as a potent and safer strategy to treat autoimmune diseases with γc cytokine upregulation.