GSK3B and rheumatoid arthritis: In addition, MOL004384 of YYH binds GSK3B with the most affinity (−9.4 kcal/mol), MOL000358 (−9.3 kcal/mol), MOL012377 (−9.2 kcal/mol), MOL012372 (−9.1 kcal/mol) of MBZ, suggesting that, for GSK3B targets, these four active ingredients are likely to bind to it and regulate RA progression.