There is emerging that evidence genes play a role in FD and other DGBIs.115 For example, FD is associated with the GNβ3 825C>T CC genotype but this gene was not linked with treatment response to antidepressants in FD.116–118 However, it remains unknown if a genetic predisposition is linked to the risk of increased small intestinal permeability, microinflammation, or immune activation in FD. The gene discussed is GNB3; the disease is Fabry disease.