LGALS1 and endophthalmitis: While we previously did not detect differences between a wildtype strain of Bc and the isogenic hbl mutant derivative strain in terms of infection progression and severity in a rabbit model of endophthalmitis (Callegan et al., 1999b), Beecher and colleagues observed that direct intravitreal injection of purified Hbl toxin resulted in significant retinal architecture disruption and elicited significant neutrophil infiltration (Beecher et al., 1995).