FN1 and systemic sclerosis: (30) validated the upregulation of 9 pro-fibrotic miRNAs and the downregulation of 8 anti-fibrotic miRNAs in exosomes derived from plasma of SSc patients and detected an upregulation of type I collagen fibers and fibronectin in normal human dermal fibroblasts stimulated by these exosomes, indicating the pro-fibrotic function of circulating exosomal miRNAs in SSc.