Remarkably, we found that while the anticipated IFN-β and IFN-λ responses were induced following infection with the MR-766 and PRVABC-59 strains (Fig. 3I–K), the ZIKVΔTNT mutant incited a remarkable 30–60-fold surge in IFN-λ1, 2, and 3 levels (Fig. 3L–M). This evidence concerns the gene IFNL1 and infection.