MAPT and Alzheimer disease: Evidence increasingly implicates regulation of microglia activation in several AD-related processes including plaque formation and growth[11], plaque compaction[11, 12], protection against dystrophic neurites[13], regulation of development and spread of Tau pathology[14], destruction of perineuronal nets[15, 16], and synaptic and neuronal loss[15, 17–20], though the role of microglia in suppressing or aggravating impacts of AD is currently unclear, and may vary with disease progression[21].