PBRM1 and neoplasm: Given the co-occurrence of VHL and PBRM1 mutations, 84%, 325/388 of PBRM1-positive tumours were also VHL mutated), after adjusting for VHL status, PBRM1 mutational status did not show an independent relationship with OS (HR = 0.68, 95% CI: 0.44–1.03).