(42) Furthermore, we identified a conserved interaction between Amyloid beta precursor protein (APP) on macrophages and tumor cells, signaling to CD74 present on hybrid cells, as well as annexin A1 (ANXA1) – formyl peptide receptor 1 (FPR1) and ANXA1-FPR3 signaling between hybrids and macrophages in four of five patients. This evidence concerns the gene APP and neoplasm.