Interestingly, ZW inhibited diabetes-induced anxiety and depression by minimizing the neuroinflammatory response by decreasing NfκB, IL-1β, and IL6 mRNA levels and the number of TNF-α- and GFAP-immunostained neurons and serum level of TNF-α and CRP because of its antioxidant power. This evidence concerns the gene NFKB1 and major depressive disorder.