IL1B and diabetes mellitus: STZ-induced diabetes exhibited severe neuroinflammation, marked by a significant p < 0.001 increase in cortical gene expression of the nuclear transcription factor NfκB, with a subsequent increase in the mRNA levels of the inflammatory cytokines IL-1β and IL6 by 463.2, 508.9, and 368.6%, respectively (Figures 4A,C,E) and immunoexpression of TNF-α by 564.5% (Figures 9C,E) relative to those in control group (Figure 9A).