Clinical studies on the potential neuroprotective function of T cells have revealed evidence of the protective function of CD4 + FOXP3+ regulatory Tregs, with the quantity of Treg cells in the blood of ALS patients negatively correlated with the rate of disease progression (Henkel et al., 2013; Rolfes et al., 2021). Here, CD4 is linked to amyotrophic lateral sclerosis.