CD8+ T cells were previously observed in the spinal cord of both ALS patients in addition to ALS SOD1G93A mouse models, and an in vivo study revealed that these cells infiltrate CNS at the symptomatic stage where selective ablation of CD8+ T cells in mice decreased spinal motoneuron loss (Ramachandran et al., 2023). Here, CD8A is linked to amyotrophic lateral sclerosis.