In comparison with the healthy controls, ALS patients were reported to have increased levels of activated CD4+ T cells in CSF, which have an essential role in the early stage of the disease (Henkel et al., 2006; Beers et al., 2008; Chiu et al., 2008) (Rolfes et al., 2021). Here, CD4 is linked to amyotrophic lateral sclerosis.