In this context, Ramachandran et al. (2023) investigated reactivity of CD8+ T cells of ALS patients and their healthy counterparts against ten TDP43-derived peptides, However, the authors revealed that TFP43 is a weak autoantigen, and the investigations aiming to elucidate the autoantigens continues. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.