TARDBP and amyotrophic lateral sclerosis: In a more recent study performed with monocyte-derived microglia-like cells obtained from ALS patients, the cells were reported to have abnormally aggregated TDP43 in the cytoplasm, which is accompanied by an increase in IL-18 levels along with IL-8, TNF-α and TGF-β (Quek et al., 2022).