Ehrhart et al. reported significant elevation of IL-6 levels in the blood samples in ALS patients; moreover, normalization of IL-6 along with IL-5 at the follow up was found to be associated with decreased IL-2 and increased IL-8 levels (Ehrhart et al., 2015), indicating that different humoral factors are involved in different inflammatory responses during the disease course. Here, CXCL8 is linked to amyotrophic lateral sclerosis.