However, in in vivo ALS models as well as in ALS patients, the dysfunction of the glutamate transporter-2 (EAAT-2) leads to decreased uptake of glutamate from astrocytes, which in turn affects the function of motoneurons (Howland et al., 2002; Dunlop et al., 2003; Pardo et al., 2006; Papadeas et al., 2011). Here, SLC1A2 is linked to amyotrophic lateral sclerosis.