By detecting the levels of DAMPs in the sera of healthy and advanced schistosomiasis patients, it was found that the levels of HMGB1 and IL-33 in the sera of advanced schistosomiasis patients were significantly higher than those of healthy patients, indicating that DAMPs may be closely correlated with liver fibrosis of schistosomiasis. Here, HMGB1 is linked to schistosomiasis.