HMGB1 promotes the proliferation and activation of HSCs to promote liver fibrosis during disease progression, and the high level of HMGB1 at the injury site recruits fibroblasts, endothelial cells and smooth muscle cells to repair tissue damage (Vicentino et al., 2018; Chen et al., 2021). The gene discussed is HMGB1; the disease is Hepatic fibrosis.