Previous studies have shown that the absence of melanoma 2 (AIM2) inflammasome activity is increased in the hippocampus of APP/PS1 mice, but the role of AIM2 in AD remains unclear.<h4>Methods</h4>Injection of Aβ<sub>1-42</sub> into the bilateral hippocampal CA1 was used to mimic an AD mouse model (AD mice). This evidence concerns the gene AIM2 and Alzheimer disease.