Signaling modifications in pathways such as Ras/MEK, PI3K/AKT, Notch, mTOR, c‐Myc, NFκB, HIF1α, as well as in epigenetic regulatory mechanisms, contribute to the reprogramming of the metabolism of certain nutrients and therefore to the plasticity and metabolic adaption of GBM [64]. Here, PIK3CA is linked to glioblastoma.