Other molecular alterations such as copy number modifications (MDM2 loss, Chromosome 7 gain, Chromosome 10 loss), gene overexpression or amplification (EGFR, PDGFRA, Notch, c‐Myc, FGFR) and epigenetic changes such as methylation (MGMT promoter methylation), are also involved in the pathogenesis of GBM [36]. The gene discussed is MYC; the disease is glioblastoma.