The suppression of LPS-stimulated ALT and AST secretion in HepG2 cells by LC27 or LC67 was positively correlated with their inhibitory effects on blood ALT and AST levels (liver damage), liver αSMA collagen levels (liver fibrosis), and liver TG and TC levels (steatohepatitis) in mice with LPS-prompted liver injury. This evidence concerns the gene ACTA1 and Hepatic fibrosis.