Known PCa-associated genomic alterations were identifiable in most copy number altered samples (e.g. Fig. 1A), including recurrent gains in chromosome arm 8q5, harboring the oncogene MYC, and losses in chromosome arms 8p, 10q, and 13q5,9, harboring known tumor suppressor genes NK3 homeobox 1 (NKX3.1), Phosphatase and tensin homolog (PTEN), and Retinoblastoma 1 (RB1), respectively. Here, RB1 is linked to posterior cortical atrophy.