Among semiquantitative parameters, 18F-FES had significantly higher SUVmax and T/N ratio than 18F-FDG PET/CT in lesions of ILC cell type, due to mostly strong ER expression (Xin and Eng 2016), low tumor density, low GLUT-1 expression, low proliferation rates, and infiltrative growth patterns (Fujii et al. 2016). Here, ESR1 is linked to neoplasm.