Around these 7 APOBEC3 genes, with an arbitrary association threshold of P < 0.01, we obtained 2 SNPs from HGI-B2-AFR and 4 SNPs from HGI-B2-EUR. Of these 6 COVID-19 risk SNPs, rs12168809 (P = 0.002; OR = 1.12; 95% CI [1.04–1.2]) and rs76929059 (P = 0.004; OR = 0.82 [0.71–0.94]) are unique to AA; they are located in the intergenic and promoter region of APOBEC3A, respectively. Here, APOBEC3A is linked to COVID-19.