EGFR and Abnormal emotional state: For instance, the 5-year predicted stroke-free survival probability was 55.1% (observed 50.8%) in CADASIL patients with episodes of mood disturbances versus 75.1% (observed 76.0%) in those without, and from 74.1% (observed 78.5%) in patients with an EGFr mutation location in domains 7 to 34 versus 71.0% (observed 68.9%) in those with an EGFr mutation location in domains 1 to 6.