EMT is a multidimensional process that involves the remodeling of the cytoskeleton, cell membrane, and cell–cell junctions, resulting in the loss of epithelial characteristics and the acquisition of mesenchymal properties facilitated by MAPK activation.279 Autophagy supplies the energy required for TGF-β–induced EMT and cancer metastasis. The gene discussed is TGFB1; the disease is cancer.