RAB27A and cancer: For example, Rab27a regulates the exocytosis of exosomes and Rab27a knockdown impairs sEV secretion in cancer models.24 Drugs such as dimethyl amiloride (DMA), heparin and 4-nitrophenyl β-D-xylopyranoside (PNP-Xyl) have also been used for a similar purpose.25–27 Still, few studies have investigated the use of these drugs in vivo and little is known about their activity on pro-metastatic signaling pathways.