Some previous studies have found that the expression of miR-27a in LPS-induced RAW264.7 macrophages was downregulation, and overexpression of miR-27a alleviated LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway [19]. This evidence concerns the gene NFKB1 and injury.