Interestingly, even though life expectancy is not extended by genetic syndromes that block GH signaling, GH-resistant, and GH-deficient individuals are significantly protected from chronic aging-associated diseases including cancer, diabetes, and atherosclerosis, show improvements in the maintenance of various physiological functions into advanced age [60], and in at least one population of IGHD individuals appear to be more likely to achieve exceptional longevity [61]. The gene discussed is GH1; the disease is diabetes mellitus.