CD247 and graft versus host disease: Unfortunately, the only other paper to address TCR-mediated function in the form of GVHD obtained differing results that may be due to an alternative design of CAR construct with mutated immunoreceptor tyrosine-based activation motifs (ITAMS) (CD3ζ X2X) and a different (minor- rather than major-mismatched) model of allogeneic transplantation [13].