The results of lung metastasis of tail vein tumor also showed that co-culturing with mimics transfected macrophages enhanced the migration ability of colon cancer cells (Fig. S5D-F).WB revealed that the expressions of increased N-cadherin, vimentin, cyclin E and cyclin D, decreased E-cadherin, in colon cancer cells co-cultured with THP1 cells transfected with mimic (Fig. S5G). This evidence concerns the gene VIM and malignant colon neoplasm.