KLF4 and atherosclerosis: Interestingly, it has been demonstrated that CH25H and LXR expressions are controlled by krüppel-like factor 4, a central anti-inflammatory transcription factor, in ECs and macrophages in vitro and in vivo models of atherosclerosis, thus suggesting an atheroprotective role of the krüppel-like factor 4–Ch25h/LXR axis (67).