This analysis showed that the FLT3-ITD-AML-specific GRN (Figure 3C), which is distinct from that of healthy PBSCs, contains a central cluster of overlapping nodes for the TF modules TCF3-Ebox, ETS, RUNX, AP-1, MEIS, NFI, C/EBP/NFIL3, IKFZ, and MYB that is also found in the shared sites (Figure 3D). Here, TCF3 is linked to acute myeloid leukemia.