Cell-type-specific gene expression is largely encoded in the distal enhancer elements physically interacting with their cognate promoters.10 Our previously constructed GRNs for AML with FLT3-ITD and FLT3-ITD/NPM1 genotypes highlighted interactions between upregulated TF families and distal elements demonstrating that each AML-subtype displayed a specific gene regulatory phenotype distinct from that of normal cells and of each other. The gene discussed is NPM1; the disease is acute myeloid leukemia.