TNF and acute myeloid leukemia: This phenomenon can also be seen in the FLT3-ITD subtype whose AML-specific GRN highlights various TF families that are associated with aberrant signaling (AP-1 family), are overexpressed (RUNX1),1,33 or are aberrantly expressed (FOXC1, NFIX).2,16 In addition, these subtype-specific deregulated TFs form regulatory modules that contain multiple signaling genes that are upregulated compared to healthy cells, such as the DUSPs or TNF superfamily members (see Figures 5A–5F).