This phenomenon can also be seen in the FLT3-ITD subtype whose AML-specific GRN highlights various TF families that are associated with aberrant signaling (AP-1 family), are overexpressed (RUNX1),1,33 or are aberrantly expressed (FOXC1, NFIX).2,16 In addition, these subtype-specific deregulated TFs form regulatory modules that contain multiple signaling genes that are upregulated compared to healthy cells, such as the DUSPs or TNF superfamily members (see Figures 5A–5F). Here, FOS is linked to acute myeloid leukemia.