RUNX1 and glioblastoma: An example for this finding is PLB1, which encodes for phospholipase B1, whose overexpression has been observed in glioblastoma and has been highlighted as an mRNA vaccine candidate (Figure 6G).28 Down-regulated genes from other modules overlapping with the RUNX1 module scoring in our screen included MATK (megakaryocyte-associated tyrosine kinase), which is an important regulator of SRC kinases in blood cells.29 The analysis of upregulated genes after CBFβi showed a strong enrichment of genes organized in the overlapping NFI, AP-1, and RUNX modules scoring in our screen (Figure S6E).