Reasons for permanent discontinuation were ALT/AST > 8 × ULN combined with a bilirubin level > 2 × ULN (n = 2), death (n = 1; due to a combination of PD and liver toxicity) and switch to another line of treatment (n = 3; 2 patients switched to sunitinib and 1 to everolimus). Here, GPT is linked to hepatotoxicity.