ChRCC cases were enriched in peak cluster 1, which showed characteristic enrichment of the binding motifs of the forkhead box (FOX) gene family, grainyhead-like transcription factor 2 (GRHL2), and oestrogen-related receptor gamma (ERRγ) (Fig. 3a and Supplementary Fig. 3a). This evidence concerns the gene GRHL2 and chromophobe renal cell carcinoma.