ERRγ was highly expressed, and its promoter region was hypomethylated in ChRCC (Fig. 6f, g), and PGC-1α, PPARγ, and FOXO1, all of which are co-activators of ERRγ, were also highly expressed in ChRCC (Supplementary Fig. 11e). Here, FOXO1 is linked to chromophobe renal cell carcinoma.