While the less severe sibling presented with generalized inflammatory nodules with keratotic plugs resembling multiple keratocanthomas, the more severely affected sibling had manifestations of familial keratosis lichenoides chronica, psoriasis and atopic dermatosis, potentially identifying a role for NLRP1 in these diseases, supporting earlier NLRP1 genetic associations with psoriasis23. Here, NLRP1 is linked to psoriasis.